Importin 11 anticorps (N-Term)

N° du produit ABIN453706

Cet anticorps Lapin Polyclonal détecte spécifiquement Importin 11 dans WB et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour Importin 11 anticorps (N-Term) (ABIN453706)

Antigène: Importin 11 (IPO11)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 11 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-Importin 11 anticorps

Épitope: N-Term

Specificité: This antibody reacts to IPO11.

Purification: Affinity chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide selected from the N-term region of human IPO11

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Importin 11

Antigène: Importin 11 (IPO11)

Autre désignation: RanBP11 / Importin-11

Sujet: IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).Synonyms: IPO11, Imp11, Ran-binding protein 11

ID gène: 51194

NCBI Accession: NP_057422

UniProt: Q9UI26

Pathways: Protein targeting to Nucleus