PKD2 anticorps (Internal Region)

N° du produit ABIN453986

Détail du produit anti-PKD2 anticorps

Antigène: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PKD2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to Polycystin 2 (PKD2).

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Bovine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-ERAKLKRREVLGR, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/2000. Western blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur PKD2

Antigène: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Autre désignation: PKD2 (PKD2 Produits)

Synonymes: anticorps APKD2, anticorps PC2, anticorps PKD4, anticorps Pc-2, anticorps TRPP2, anticorps C030034P18Rik, anticorps RGD1559992, anticorps pkd2, anticorps trpp2, anticorps Cup, anticorps PKD2L1, anticorps polycystin 2, transient receptor potential cation channel, anticorps polycystic kidney disease 2, anticorps Polycystin-2, anticorps polycystin 2, transient receptor potential cation channel L homeolog, anticorps PKD2, anticorps Pkd2, anticorps pkd-2, anticorps pkd2.L, anticorps pkd2

Sujet: Mutations in the polycystin 2 gene are thought to be involved in autosomal dominant polycystic kidney disease, a condition characterised by renal cyst formation. Polycystin 2 has multiple membrane spanning domains with C and N terminal cytoplasmic domains, and has been found to be localised to the plasma membrane, ER and Golgi in various cell types and in cilia. It is thought to be involved in calcium signaling and transport and has been implicated in the development and morphology of renal tubules. It has been found to be regulated by EGF signalling. Interaction with polycystin 1 via the C terminus of both proteins is thought to be important for its function.Synonyms: Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystin-2, Polycystwin, R48321

ID gène: 5311

NCBI Accession: NP_000288

UniProt: Q13563

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity