Aperçu rapide pour Tacrolimus (FK506) anticorps (ABIN472100)
Antigène
Tacrolimus (FK506)
Hôte
Souris
Clonalité
Monoclonal
Conjugué
Inconjugué
Application
ELISA
Clone
FK1
Specificité
Detects FK-506, a macrolide with similar but more potent immunosuppressant activity than cyclosporine. It is a 23-membered lactone produced by the bacteria Streptomyces tsukubaensis. FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogeneic organ transplantation to reduce organ rejection. Side effects of FK-506 treatment include nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension.