Methotrexate anticorps

N° du produit ABIN487772

Détail du produit anti-Methotrexate anticorps

Antigène: Methotrexate (MTX)

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp Methotrexate est non-conjugé

Application: Enzyme Immunoassay (EIA)

Purification: Ig Fraction

Immunogène: Methotrexate -BSA

Isotype: IgG

Information d'application

Indications d'application: ELISA: 2.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 7.74 mg/mL (U.V.abs at 280nm)

Buffer: 20 mM Phosphate, 150 mM Sodium Chloride, pH 7.2 containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur Methotrexate

Antigène: Methotrexate (MTX)

Autre désignation: Methotrexate (MTX Produits)

Classe de substances: Amino Acid

Sujet: Methotrexate (rINN) abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases and as an abortifacient in the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about one thousand-fold that of folate for DHFR. Methotrexate acts specifically during DNA and RNA synthesis, and thus it is cytotoxic during the S-phase of the cell cycle. Logically, it therefore has a greater toxic effect on rapidly dividing cells which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells. Lower doses of methotrexate have been shown to be very effective for the management of rheumatoid arthritis, Crohn's disease, and psoriasis.Synonyms: 4-amino-10-methylpteroyl-L-glutamic acid