PLA2R1 anticorps (Internal Region)

N° du produit ABIN487965

Cet anticorps anti-PLA2R1 Polyclonal Chèvre (ABIN487965) détecte spécifiquement PLA2R1 dans WB et EIA. L’anticorps est réactif avec des échantillons de Humain, Boeuf (Vache) et Chien.

Aperçu rapide pour PLA2R1 anticorps (Internal Region) (ABIN487965)

Antigène: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Reactivité: Humain, Boeuf (Vache), Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PLA2R1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-PLA2R1 anticorps

Épitope: Internal Region

Séquence: c-EKKKDTPKQH GT

Specificité: This antibody is expected to recognize all reported isoforms (NP_031392.3, NP_001007268.1, NP_001182570.1) of PLA2R1.

Réactivité croisée (Details): Species reactivity (expected):Canine (Dog), Pig.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the Internal region of the protein sequence according to NP_031392.3, NP_001007268.1.

Information d'application

Indications d'application: Peptide ELISA: 1/64000. Western blot: Approx 140 kDa band observed in Human Ileum lysates (calculated MW of150 kDa according to NP_001007268.1). Recommended concentration: 1 - 3 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur PLA2R1

Antigène: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Autre désignation: PLA2R1 / PLA2R

Sujet: PLA2R is a receptor for secretory phospholipase A2 (sPLA2). It acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, and selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. PLA2R may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.Synonyms: 180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, CLEC13C, M-type receptor, PLA2-R, Secretory phospholipase A2 receptor

ID gène: 22925

NCBI Accession: NP_001007268

UniProt: Q13018

Pathways: Positive Regulation of Response to DNA Damage Stimulus