CASR anticorps (AA 926-1078)

N° du produit ABIN4886502

Détail du produit anti-CASR anticorps

Antigène: CASR (Calcium-Sensing Receptor (CASR))

Épitope: AA 926-1078

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Extracellular calcium-sensing receptor(CASR) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Extracellular calcium-sensing receptor(CASR) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: calcium sensing receptor
Protein Name: Extracellular calcium-sensing receptor

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-CASR (ABIN4886502)

Yuan, Shi, Li, Yang, Tang, Hu, Du, Li, Gu, Wang, Xi, Tang: "Evaluation of a TPTX model induced by ischemia." dans: Experimental animals, Vol. 66, Issue 4, pp. 345-356, (2018) (PubMed).

Détails sur CASR

Antigène: CASR (Calcium-Sensing Receptor (CASR))

Autre désignation: CASR (CASR Produits)

Synonymes: anticorps CAR, anticorps EIG8, anticorps FHH, anticorps FIH, anticorps GPRC2A, anticorps HHC, anticorps HHC1, anticorps HYPOC1, anticorps NSHPT, anticorps PCAR1, anticorps CaR, anticorps Gprc2a, anticorps gprc2a, anticorps xV2R F-1, anticorps CASR, anticorps calcium sensing receptor, anticorps calcium-sensing receptor, anticorps calcium-sensing receptor L homeolog, anticorps CASR, anticorps Casr, anticorps casr.L

Sujet: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Synonyms: Ca sensing receptor | CAR | CaSR | EIG8 | EIG 8 | FHH | FIH | GPRC2A | HHC | HHC1 | NSHPT | PCAR 1 | PCaR1 | P41180

ID gène: 846

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis