CPB2 anticorps (AA 166-388)

N° du produit ABIN4886545

Cet anticorps Lapin Polyclonal détecte spécifiquement CPB2 dans WB, IHC et ELISA. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour CPB2 anticorps (AA 166-388) (ABIN4886545)

Antigène: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CPB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-CPB2 anticorps

Épitope: AA 166-388

Fonction: Anti-Carboxypeptidase B2/CPB2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Carboxypeptidase B2/CPB2 Antibody Picoband® (ABIN4886545). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human CPB2 recombinant protein (Position: K166-D388). Human CPB2 shares 86.1% and 85.7% amino acid (aa) sequence identity with mouse and rat CPB2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
ELISA(Cap) , 1-5 μg/mL, Human, -
1. Boffa MB, Reid TS, Joo E, Nesheim ME, Koschinsky ML (May 1999). "Characterization of the gene encoding human TAFI (thrombin-activable fibrinolysis inhibitor, plasma procarboxypeptidase B)". Biochemistry 38 (20): 6547-58. 2. Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D (Dec 1991). "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma". J Biol Chem 266 (32): 21833-8. 3. Tsai SP, Drayna D (Dec 1992). "The gene encoding human plasma carboxypeptidase B (CPB2) resides on chromosome 13". Genomics14 (2): 549-50.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Références pour anticorps anti-CPB2 (ABIN4886545)

Qin, Zeng, Tian, Deng, Ren, Zheng, Li, Li, Liao, Chen: "Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats." dans: Clinical and experimental pharmacology & physiology, Vol. 36, Issue 3, pp. 319-24, (2009) (PubMed).

Détails sur CPB2

Antigène: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Autre désignation: CPB2

Sujet:

Synonyms: Carboxypeptidase B2,3.4.17.20 ,Carboxypeptidase U,CPU,Plasma carboxypeptidase B,pCPB,Thrombin-activable fibrinolysis inhibitor,TAFI,CPB2,

Tissue Specificity: Plasma, synthesized in the liver.

Background: Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Poids moléculaire: 48 kDa, 60 kDa

ID gène: 1361

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis