MLKL anticorps (pSer358)

N° du produit ABIN4901948

L’anticorps Souris Monoclonal anti-MLKL a été validé pour IHC (p). Il convient pour détecter MLKL dans des échantillons de Humain.

Aperçu rapide pour MLKL anticorps (pSer358) (ABIN4901948)

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MLKL est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6F8

Détail du produit anti-MLKL anticorps

Épitope: pSer358

Fonction: MLKL is a protein encoded by the MLKL gene which is approximately 54,4 kDa. MLKL is localised to the cell membrane and cytoplasm. It is involved in the dimerization of procaspase-8, the TNF signalling pathway, apoptosis and autophagy. This protein falls under the protein kinase superfamily. It plays a critical role in tumour necrosis factor-induced necroptosis which is a programmed cell death process. It does this via interaction with the receptor-interacting protein 3 which is a key signalling molecule in necroptosis pathway. MLKL is expressed in the heart, intestine and lung. STJ97776 was developed from clone 6F8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen MLKL. This primary antibody specifically binds to endogenous MLKL protein which only binds about S358 when S358 is phosphorylated.

Specificité: Phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8) detects endogenous levels of MLKL

Attributs du produit: Mouse Monoclonal to phospho-MLKL (S358).

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogène: synthetic peptide derived from phospho-MLKL (S358)

Isotype: IgG1

Information d'application

Indications d'application: IHC 1:100-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur MLKL

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Autre désignation: MLKL

ID gène: 197259

UniProt: Q8NB16