MASTL anticorps

N° du produit ABIN4911795

Cet anticorps anti-MASTL Monoclonal Souris (Clone 5C3) (ABIN4911795) détecte spécifiquement MASTL dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MASTL anticorps (ABIN4911795)

Antigène: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MASTL est non-conjugé

Application: Western Blotting (WB)

Clone: 5C3

Détail du produit anti-MASTL anticorps

Réactivité croisée: Humain

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogène: This MASTL monoclonal antibody is generated from mouse immunized with MASTL recombinant protein.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MASTL

Antigène: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Autre désignation: MASTL

Sujet:

Synonyms: GW, GWL, THC2, MAST-L, GREATWALL, Serine/threonine-protein kinase greatwall, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MASTL

Background: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

ID gène: 84930

UniProt: Q96GX5