C6orf150 anticorps (AA 1-185)

N° du produit ABIN4911805

Détail du produit anti-C6orf150 anticorps

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Épitope: AA 1-185

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C6orf150 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Purified by Protein G.

Immunogène: This MB21D1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-185 amino acids from human MB21D1.

Clone: 7E3

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur C6orf150

Antigène: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Autre désignation: MB21D1 (C6orf150 Produits)

Synonymes: anticorps C6orf150, anticorps cGAS, anticorps h-cGAS, anticorps Mab-21 domain containing 1, anticorps cyclic GMP-AMP synthase, anticorps MB21D1, anticorps CGAS

Sujet:

Synonyms: cGAS, h-cGAS, C6orf150, Cyclic GMP-AMP synthase, cGAMP synthase, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1, MB21D1

Background: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).

ID gène: 115004

UniProt: Q8N884

Pathways: Activation of Innate immune Response