RAB13 anticorps

N° du produit ABIN4913382

Détail du produit anti-RAB13 anticorps

Antigène: RAB13 (RAB13, Member RAS Oncogene Family (RAB13))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RAB13 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Purified by Protein G.

Immunogène: This RAB13 antibody is generated from a mouse immunized with a recombinant protein between 1-203 amino acids from human RAB13.

Clone: 5C9

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur RAB13

Antigène: RAB13 (RAB13, Member RAS Oncogene Family (RAB13))

Autre désignation: RAB13 (RAB13 Produits)

Synonymes: anticorps cb764, anticorps hm:zeh0455, anticorps RAB13, anticorps 0610007N03Rik, anticorps B230212B15Rik, anticorps RAB13, member RAS oncogene family, anticorps rab13, anticorps RAB13, anticorps Rab13

Sujet:

Synonyms: GIG4, Ras-related protein Rab-13, Cell growth-inhibiting gene 4 protein, RAB13

Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.

ID gène: 5872

UniProt: P51153

Pathways: Cell-Cell Junction Organization