SP1 anticorps

N° du produit ABIN4914245

L’anticorps Souris Monoclonal anti-SP1 a été validé pour WB et IF. Il convient pour détecter SP1 dans des échantillons de Humain.

Aperçu rapide pour SP1 anticorps (ABIN4914245)

Antigène: SP1 (Sp1 Transcription Factor (SP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 6C6

Détail du produit anti-SP1 anticorps

Réactivité croisée: Humain

Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This SP1 antibody is generated from a mouse immunized with a recombination protein from the human SP1.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000
IF()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SP1

Antigène: SP1 (Sp1 Transcription Factor (SP1))

Autre désignation: SP1

Sujet:

Synonyms: Transcription factor Sp1, SP1, TSFP1

Background: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.

ID gène: 6667

UniProt: P08047

Pathways: Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction