VRK1 anticorps

N° du produit ABIN4915154

L’anticorps Souris Monoclonal anti-VRK1 a été validé pour WB. Il convient pour détecter VRK1 dans des échantillons de Humain.

Aperçu rapide pour VRK1 anticorps (ABIN4915154)

Antigène: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp VRK1 est non-conjugé

Application: Western Blotting (WB)

Clone: 5C1

Détail du produit anti-VRK1 anticorps

Réactivité croisée: Humain

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogène: Purified His-tagged VRK1 protein was used to produced this monoclonal antibody.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur VRK1

Antigène: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Autre désignation: VRK1

Sujet:

Synonyms: PCH1, PCH1A, Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1, VRK1

Background: Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.

ID gène: 7443

UniProt: Q99986