Desmoglein 1 anticorps (Internal Region)

N° du produit ABIN4949605

L’anticorps Souris Monoclonal anti-Desmoglein 1 a été validé pour WB, IF, FACS et IP. Il convient pour détecter Desmoglein 1 dans des échantillons de Humain.

Aperçu rapide pour Desmoglein 1 anticorps (Internal Region) (ABIN4949605)

Antigène: Desmoglein 1 (DSG1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: 27B2

Détail du produit anti-Desmoglein 1 anticorps

Épitope: Internal Region

Purification: Protein G affinity chromatography

Immunogène: A recombinant protein corresponding to the intracellular domain of human Desmoglein 1 was used as the immunogen for the DSG1 antibody.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal dilution of the DSG1 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,WB: 0.5-1 μg/mL,Immunoprecipitation: suitable

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the DSG1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur Desmoglein 1

Antigène: Desmoglein 1 (DSG1)

Autre désignation: Desmoglein 1 / DSG1

Sujet: Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Pathways: Cell-Cell Junction Organization