Desmoglein 1 anticorps (Intracellular)

N° du produit ABIN4949605

L’anticorps anti-Desmoglein 1 Monoclonal Souris est utilisé pour la détection de Desmoglein 1 dans des échantillons de Humain. Il a été validé pour WB, IF et FACS.

Aperçu rapide pour Desmoglein 1 anticorps (Intracellular) (ABIN4949605)

Antigène: Desmoglein 1 (DSG1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: 27B2

Détail du produit anti-Desmoglein 1 anticorps

Épitope: Intracellular

Fonction: DSG1 Antibody / Desmoglein 1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A recombinant protein corresponding to the intracellular domain of human Desmoglein 1 was used as the immunogen for the DSG1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the DSG1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the DSG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Desmoglein 1

Antigène: Desmoglein 1 (DSG1)

Autre désignation: DSG1

Sujet: Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

UniProt: Q02413

Pathways: Cell-Cell Junction Organization