FSHR anticorps (full length)

N° du produit ABIN4949699

Cet anticorps anti-FSHR Monoclonal Souris (Clone FSHR-1400) (ABIN4949699) détecte spécifiquement FSHR dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour FSHR anticorps (full length) (ABIN4949699)

Antigène: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FSHR est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: FSHR-1400

Détail du produit anti-FSHR anticorps

Épitope: full length

Fonction: FSHR Antibody / FSH Receptor (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A human full length recombinant protein was used as the immunogen for this FSHR antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FSHR antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the FSHR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur FSHR

Antigène: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Autre désignation: FSHR

Sujet: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome, a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

UniProt: P23945

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling