Thymidine Phosphorylase anticorps

N° du produit ABIN4949902

Détail du produit anti-Thymidine Phosphorylase anticorps

Antigène: Thymidine Phosphorylase (TYMP)

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thymidine Phosphorylase est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Protein G affinity chromatography

Immunogène: Human recombinant full length protein was used as the immunogen for this Thymidine Phosphorylase antibody.

Clone: SPM322

Isotype: IgG1

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Thymidine Phosphorylase antibody to be titered up or down for optimal performance.\. IP: 1-2 μg/500 μg lysate,IHC (FFPE): 1-2 μg/mL for 30 min at RT,WB: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Thymidine Phosphorylase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur Thymidine Phosphorylase

Antigène: Thymidine Phosphorylase (TYMP)

Autre désignation: Thymidine Phosphorylase / PD-ECGF (TYMP Produits)

Synonymes: anticorps ECGF, anticorps ECGF1, anticorps MEDPS1, anticorps MNGIE, anticorps MTDPS1, anticorps PDECGF, anticorps TP, anticorps hPD-ECGF, anticorps 2900072D10Rik, anticorps Ecgf1, anticorps PD-ECGF, anticorps Pdgfec, anticorps typh, anticorps thymidine phosphorylase, anticorps thymidine phosphorylase DeoA, anticorps AMP phosphorylase, anticorps Thymidine phosphorylase, anticorps TYMP, anticorps Tymp, anticorps deoA, anticorps Dd586_0614, anticorps Kvar_4413, anticorps NMAG_RS19330, anticorps Snov_1187, anticorps Fbal_2856, anticorps Ftrac_2071, anticorps Intca_1216, anticorps ARCVE_RS10415, anticorps Sphch_4174, anticorps Sinme_3461, anticorps METOK_RS06355, anticorps Mesop_1831, anticorps typh

Sujet: Recognizes a 485 amino acid protein (55 kDa monomer / 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), also called Thymidine Phosphorylase (TP, Tymp) or Gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2