KEAP1 anticorps (AA 422-449)

N° du produit ABIN3031533

Détail du produit anti-KEAP1 anticorps

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Épitope: AA 422-449

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée (Details): Expected species reactivity: Pig

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 422-449 from the human protein was used as the immunogen for this KEAP1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the KEAP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at 4°C for up to one month. For long term, aliquot the KEAP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: KEAP1 (KEAP1 Produits)

Synonymes: anticorps INrf2, anticorps KLHL19, anticorps INRF2, anticorps mKIAA0132, anticorps Inrf2, anticorps fb36f11, anticorps keap1, anticorps wu:fb36f11, anticorps KEAP1, anticorps klhl19, anticorps zgc:171654, anticorps kelch like ECH associated protein 1, anticorps kelch-like ECH-associated protein 1, anticorps Kelch-like ECH-associated protein 1, anticorps kelch-like ECH-associated protein 1a, anticorps kelch like ECH associated protein 1 L homeolog, anticorps kelch-like ECH-associated protein 1b, anticorps KEAP1, anticorps Keap1, anticorps keap1a, anticorps keap1, anticorps keap1.L, anticorps keap1b

Sujet: KEAP1 acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome [UniProt]

UniProt: Q14145

Pathways: Maintenance of Protein Location