SNAIL anticorps (AA 9-39)

N° du produit ABIN3032657

L’anticorps Lapin Polyclonal anti-SNAIL a été validé pour WB, ELISA et IHC. Il convient pour détecter SNAIL dans des échantillons de Humain.

Aperçu rapide pour SNAIL anticorps (AA 9-39) (ABIN3032657)

Antigène: SNAIL (SNAI1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNAIL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SNAIL anticorps

Épitope: AA 9-39

Purification: Purified

Immunogène: A portion of amino acids 9-39 from the human protein was used as the immunogen for this anti-SNAIL antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the anti-SNAIL antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the anti-SNAIL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SNAIL

Antigène: SNAIL (SNAI1)

Sujet: The Drosophila embryonic protein SNAI1, commonly known as Snail, is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. SNAI1 zinc-fingers (ZF) binds to E-box, an E-cadherin promoter region, and represses the expression of the adhesion molecule, which induces the tightly bound epithelial cells to break loose from each other and migrate into the developing embryo to become mesenchymal cells. This process allows for the formation of the mesodermal layer in the developing embryo. Though SNAI1 is shown to repress expression of E-cadherin in epithelial cells, studies have shown homozygous mutant embryos are still able to form a mesodermal layer. However, the mesodermal layer present shows characteristics of epithelial cells and not mesenchymal cells (the mutant mesoderm cells exhibited a polarized state). Other studies show that mutation of specific ZFs contribute to a decrease in SNAI1 E-cadherin repression. [Wiki]

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling