Androgen Receptor anticorps (AA 282-309)

N° du produit ABIN3029942

L’anticorps anti-Androgen Receptor Polyclonal Lapin est utilisé pour la détection de Androgen Receptor dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour Androgen Receptor anticorps (AA 282-309) (ABIN3029942)

Antigène: Androgen Receptor (AR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Androgen Receptor est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Androgen Receptor anticorps

Épitope: AA 282-309

Réactivité croisée (Details): Expected species reactivity: Primate

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 282-309 from the human protein was used as the immunogen for this AR antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the AR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the AR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Androgen Receptor

Antigène: Androgen Receptor (AR)

Autre désignation: AR

Sujet: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding