BACE2C anticorps (AA 310-339)

N° du produit ABIN3029795

Détail du produit anti-BACE2C anticorps

Antigène: BACE2C (BACE2 C) (beta-Site APP-Cleaving Enzyme 2 C (BACE2 C))

Épitope: AA 310-339

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BACE2C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Purified

Immunogène: A portion of amino acids 310-339 from the human protein was used as the immunogen for this BACE2C antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the BACE2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the BACE2C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur BACE2C

Antigène: BACE2C (BACE2 C) (beta-Site APP-Cleaving Enzyme 2 C (BACE2 C))

Autre désignation: BACE2C (BACE2 C Produits)

Sujet: Amyloid-beta peptide aggregation is a signature of Alzheimer disease and a frequent complication of adult Down syndrome patients. Amyloid-beta is generated by proteolytic processing of the amyloid precursor protein (APP) by beta- and gamma-secretase at the N and C termini, respectively. Presenilin-1 is involved in the gamma-secretase activity. BACE is a transmembrane aspartyl protease with beta-secretase activity. BACE2, also termed ALP56 has 2 pepsin-like active centers, a signal sequence, a propeptide, and a long C-terminal extension including a transmembrane domain, with expression in a wide array of tissues. Northern blot analysis revealed low expression of 2.0- and 2.6-kb BACE2 transcripts in most fetal and adult tissues, with higher expression in adult colon, kidney, pancreas, placenta, prostate, stomach, and trachea. Low levels were also detected in brain, with somewhat higher expression in medulla and spinal cord. In situ hybridization analysis of rat brain found low-level BACE2 expression in contrast to BACE expression. The BACE2 expression pattern does not appear to be consistent with that of a beta-secretase. BACE2 has been mapped to 21q22.3, within the Down syndrome critical region.

UniProt: Q9Y5Z0