CD163 anticorps (AA 245-274)

N° du produit ABIN3030360

Cet anticorps anti-CD163 est un anticorps Lapin Polyclonal détectant CD163 dans WB, IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour CD163 anticorps (AA 245-274) (ABIN3030360)

Antigène: CD163

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD163 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-CD163 anticorps

Épitope: AA 245-274

Purification: Purified

Immunogène: A portion of amino acids 245-274 from the human protein was used as the immunogen for this CD163 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the CD163 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CD163 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD163

Antigène: CD163

Autre désignation: CD163

Sujet: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.

UniProt: Q86VB7