CD163 anticorps (AA 245-274)
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- Antigène Voir toutes CD163 Anticorps
- CD163
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Épitope
- AA 245-274
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CD163 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Purification
- Purified
- Immunogène
- A portion of amino acids 245-274 from the human protein was used as the immunogen for this CD163 antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product CD163 Anticorps primaire
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- Indications d'application
- Titration of the CD163 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS pH 7.4 with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot the CD163 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Antigène
- CD163
- Autre désignation
- CD163 (CD163 Produits)
- Synonymes
- anticorps DMBT1, anticorps CD163, anticorps CD163v2, anticorps CD163v3, anticorps M130, anticorps MM130, anticorps deleted in malignant brain tumors 1 protein-like, anticorps CD163 molecule, anticorps CD163 antigen, anticorps LOC426820, anticorps CD163, anticorps Cd163
- Sujet
- CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
- UniProt
- Q86VB7
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