CXCR3 anticorps (AA 140-167)

N° du produit ABIN3030510

Cet anticorps anti-CXCR3 est un anticorps Lapin Polyclonal détectant CXCR3 dans FACS, WB, ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour CXCR3 anticorps (AA 140-167) (ABIN3030510)

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXCR3 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-CXCR3 anticorps

Épitope: AA 140-167

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 140-167 from the human protein was used as the immunogen for this CXCR3 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the CXCR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CXCR3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur CXCR3

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Autre désignation: CXCR3

Sujet: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: P49682