Dynamin 1-Like anticorps (C-Term)

N° du produit ABIN3030780

Cet anticorps anti-Dynamin 1-Like est un anticorps Lapin Polyclonal détectant Dynamin 1-Like dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Dynamin 1-Like anticorps (C-Term) (ABIN3030780)

Antigène: Dynamin 1-Like (DNM1L)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dynamin 1-Like est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Dynamin 1-Like anticorps

Épitope: C-Term

Purification: Antigen affinity purified

Immunogène: This DNM1L antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 513-547 amino acids from the C-terminal region of human DRP1/DNM1L.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the DNM1L antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:8000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the DNM1L antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Dynamin 1-Like

Antigène: Dynamin 1-Like (DNM1L)

Autre désignation: DNM1L

Sujet: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. [UniProt]

UniProt: O00429