DNMT3A anticorps (AA 457-486)

N° du produit ABIN3030750

Cet anticorps anti-DNMT3A Polyclonal Lapin (ABIN3030750) détecte spécifiquement DNMT3A dans WB, ELISA et IHC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour DNMT3A anticorps (AA 457-486) (ABIN3030750)

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT3A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-DNMT3A anticorps

Épitope: AA 457-486

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat, Chicken

Purification: Purified

Immunogène: A portion of amino acids 457-486 from the human protein was used as the immunogen for this Dnmt3a antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Dnmt3a antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Dnmt3a antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur DNMT3A

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Autre désignation: Dnmt3a

Sujet: Dnmt3a is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [UniProt]

UniProt: Q9Y6K1