GFAP anticorps (N-Term)

N° du produit ABIN3028680

Cet anticorps anti-GFAP Polyclonal Lapin (ABIN3028680) détecte spécifiquement GFAP dans WB, IHC et ELISA. L’anticorps est réactif avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour GFAP anticorps (N-Term) (ABIN3028680)

Antigène: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-GFAP anticorps

Épitope: AA 2-36, N-Term

Fonction: Zebrafish Gfap Antibody

Purification: Antigen affinity

Immunogène: This Gfap antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 2-36 amino acids from the N-terminal region of zebrafish Gfap.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Gfap antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Gfap antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur GFAP

Antigène: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Autre désignation: Gfap

Sujet: Glial fibrillary acidic protein (GFAP) is a major intermediate filament protein expressed in astroglial cells and radial glia of the central nervous system (CNS). In zebrafish (Danio rerio), GFAP serves as a key structural and functional component of glial cells, particularly radial glial progenitors, which play essential roles in CNS development, neurogenesis, and regeneration.

Zebrafish GFAP shares significant structural and functional homology with mammalian GFAP, including a conserved α-helical rod domain crucial for filament assembly. It is prominently expressed during embryonic development and persists in specific glial populations in the adult brain and spinal cord. Unlike in mammals, radial glia expressing GFAP remain active as neural stem cells in the adult zebrafish CNS, making GFAP an important marker for studying neurodevelopment and regeneration.

GFAP expression in zebrafish is widely used as a glial cell marker in developmental biology, neural stem cell research, and models of CNS injury and repair. Its upregulation is also indicative of reactive gliosis following CNS trauma.

UniProt: Q58EE9