L1CAM anticorps (AA 1154-1182)

N° du produit ABIN3031578

Détail du produit anti-L1CAM anticorps

Antigène: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Épitope: AA 1154-1182

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp L1CAM est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): Expected species reactivity: Rat

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 1154-1182 from the human protein was used as the immunogen for this L1CAM antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the L1CAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. Cleavage by ADAM10 results in 180 and 40 kDa bands while cleavage by Plasmin results in 140 and 80 kDa bands.\. Western blot: 1:1000 (1)

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the L1CAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur L1CAM

Antigène: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Autre désignation: L1CAM (L1CAM Produits)

Synonymes: anticorps l1cam-a, anticorps CAML1, anticorps CD171, anticorps HSAS, anticorps HSAS1, anticorps MASA, anticorps MIC5, anticorps N-CAM-L1, anticorps N-CAML1, anticorps NCAM-L1, anticorps S10, anticorps SPG1, anticorps L1, anticorps Hsas, anticorps Hyd, anticorps NCAML1, anticorps L1 cell adhesion molecule S homeolog, anticorps L1 cell adhesion molecule, anticorps l1cam.S, anticorps L1CAM, anticorps L1cam

Sujet: L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

UniProt: P32004

Pathways: Synaptic Membrane