NEK2 anticorps (AA 350-382)

N° du produit ABIN3031999

Cet anticorps Lapin Polyclonal détecte spécifiquement NEK2 dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour NEK2 anticorps (AA 350-382) (ABIN3031999)

Antigène: NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEK2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-NEK2 anticorps

Épitope: AA 350-382

Purification: Purified

Immunogène: A portion of amino acids 350-382 from the human protein was used as the immunogen for this NEK2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the NEK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the NEK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur NEK2

Antigène: NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

Autre désignation: NEK2

Sujet: NEK2 is closely related in its catalytic domain to the serine/threonine protein kinase NIMA of Aspergillus nidulans which is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Like NIMA, the Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2. These observations demonstrate that NEK2 resembles Aspergillus NIMA, both in its catalytic domain, and cell cycle-dependent expression. Recombinant NEK2 is active as a serine/threonine-specific protein kinase and may undergo autophosphorylation. Both human NEK2 and fungal NIMA phosphorylate a similar, but not identical, set of proteins and synthetic peptides. NEK2 is shown to be expressed most abundantly in adult testis and there is increasing evidence that NEK2 is abnormally expressed in a wide variety of human cancers. This antibody is specific to isoform 2 of NEK2.

UniProt: P51955

Pathways: M Phase