PAK7 anticorps (AA 128-157)

N° du produit ABIN3028909

Cet anticorps Lapin Polyclonal détecte spécifiquement PAK7 dans WB, IHC et ELISA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour PAK7 anticorps (AA 128-157) (ABIN3028909)

Antigène: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAK7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-PAK7 anticorps

Épitope: AA 128-157

Fonction: Pak7 Antibody / Pak5

Réactivité croisée (Details): Expected species reactivity: Rat

Purification: Antigen affinity

Immunogène: A portion of amino acids 128-157 from the mouse protein was used as the immunogen for this Pak7 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Pak7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Pak7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PAK7

Antigène: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Autre désignation: Pak7

Sujet: Pak7, also called Pak5, is a serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity). [UniProt]

UniProt: Q8C015