MAP2 anticorps (pSer1539)

N° du produit ABIN3031685

L’anticorps anti-MAP2 Polyclonal Lapin est utilisé pour la détection de MAP2 dans des échantillons de Humain. Il a été validé pour ELISA et DB.

Aperçu rapide pour MAP2 anticorps (pSer1539) (ABIN3031685)

Antigène: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP2 est non-conjugé

Application: ELISA, Dot Blot (DB)

Détail du produit anti-MAP2 anticorps

Épitope: pSer1539

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat

Purification: Antigen affinity purified

Immunogène: This phospho-MAP2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1539 of human MAP2.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the phospho-MAP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the phospho-MAP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur MAP2

Antigène: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Autre désignation: MAP2

Sujet: MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2, two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.

UniProt: P11137