Nanog anticorps (pSer285)

N° du produit ABIN3031941

Cet anticorps anti-Nanog est un anticorps Lapin Polyclonal détectant Nanog dans ELISA et DB. Adapté pour Humain.

Aperçu rapide pour Nanog anticorps (pSer285) (ABIN3031941)

Antigène: Nanog (NANOG) (Nanog Homeobox (NANOG))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nanog est non-conjugé

Application: ELISA, Dot Blot (DB)

Détail du produit anti-Nanog anticorps

Épitope: pSer285

Purification: Antigen affinity purified

Immunogène: This phospho-NANOG antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS285 of human Nanog.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the phospho-NANOG antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the phospho-NANOG antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Nanog

Antigène: Nanog (NANOG) (Nanog Homeobox (NANOG))

Autre désignation: NANOG

Sujet: NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cels proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.

UniProt: Q9H9S0

Pathways: Stem Cell Maintenance