PROX1 anticorps (AA 492-522)

N° du produit ABIN3032348

L’anticorps anti-PROX1 Polyclonal Lapin est utilisé pour la détection de PROX1 dans des échantillons de Humain et Rat. Il a été validé pour WB, ELISA et IF.

Aperçu rapide pour PROX1 anticorps (AA 492-522) (ABIN3032348)

Antigène: PROX1 (Prospero Homeobox 1 (PROX1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PROX1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-PROX1 anticorps

Épitope: AA 492-522

Fonction: PROX1 Antibody / Prospero homeobox 1

Réactivité croisée (Details): Expected species reactivity: Mouse

Purification: Purified

Immunogène: A portion of amino acids 492-522 from the human protein was used as the immunogen for this PROX1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the PROX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the PROX1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PROX1

Antigène: PROX1 (Prospero Homeobox 1 (PROX1))

Autre désignation: PROX1

Sujet: The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens.

UniProt: Q92786

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation