SETD8 anticorps (N-Term)

N° du produit ABIN3032551

Cet anticorps Souris Monoclonal détecte spécifiquement SETD8 dans WB, ELISA, IHC et IF. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour SETD8 anticorps (N-Term) (ABIN3032551)

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SETD8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 43AT551-86

Détail du produit anti-SETD8 anticorps

Épitope: N-Term

Purification: Purified

Immunogène: This SET07 antibody was raised using purified recombinant GST fusion protein encoding the N-terminal region of human SET07.

Isotype: IgG1

Information d'application

Indications d'application: Titration of the SET07 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SET07 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SETD8

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Autre désignation: SET07

Sujet: SET07 is a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [UniProt]

UniProt: Q9NQR1