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NCOA1 anticorps (AA 186-214)

NCOA1 Reactivité: Humain WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3032056
  • Antigène Voir toutes NCOA1 Anticorps
    NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
    Épitope
    • 15
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 186-214
    Reactivité
    • 66
    • 46
    • 18
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 73
    • 8
    Lapin
    Clonalité
    • 63
    • 18
    Polyclonal
    Conjugué
    • 41
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NCOA1 est non-conjugé
    Application
    • 53
    • 15
    • 13
    • 13
    • 12
    • 9
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Réactivité croisée (Details)
    Expected species reactivity: Pig
    Purification
    Purified
    Immunogène
    A portion of amino acids 186-214 from the human protein was used as the immunogen for this SRC-1 antibody.
    Isotype
    Ig Fraction
  • Indications d'application
    Titration of the SRC-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot the SRC-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Antigène
    NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
    Autre désignation
    SRC-1 (NCOA1 Produits)
    Synonymes
    anticorps F-SRC-1, anticorps KAT13A, anticorps RIP160, anticorps SRC1, anticorps bHLHe42, anticorps bHLHe74, anticorps si:dkey-5g7.6, anticorps si:dkey-34f16.6, anticorps NCOA1, anticorps SRC-1, anticorps nuclear receptor coactivator 1, anticorps NCOA1, anticorps ncoa1, anticorps Ncoa1
    Sujet
    SRC-1/NCOA1 is a nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. [UniProt]
    UniProt
    Q15788
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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