SYK anticorps (AA 195-223)
Aperçu rapide pour SYK anticorps (AA 195-223) (ABIN3032716)
Antigène
Voir toutes SYK AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 195-223
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Réactivité croisée (Details)
- Expected species reactivity: Chicken, Rat
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Purification
- Antigen affinity purified
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Immunogène
- A portion of amino acids 195-223 from the mouse protein was used as the immunogen for this Syk antibody.
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Isotype
- Ig Fraction
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Indications d'application
- Titration of the Syk antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Aliquot the Syk antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- SYK (Spleen tyrosine Kinase (SYK))
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Autre désignation
- Syk
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Sujet
- Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Phosphorylates USP25 and regulates its intracellular levels (By similarity).
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UniProt
- P48025
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Pathways
- Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
Antigène
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