TFE3 anticorps (AA 1-30)

N° du produit ABIN3029200

Cet anticorps Lapin Polyclonal détecte spécifiquement TFE3 dans WB, ELISA et IF. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour TFE3 anticorps (AA 1-30) (ABIN3029200)

Antigène: TFE3 (Transcription Factor E3 (TFE3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TFE3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-TFE3 anticorps

Épitope: AA 1-30

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 1-30 from the human protein was used as the immunogen for this TFE3 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the TFE3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TFE3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur TFE3

Antigène: TFE3 (Transcription Factor E3 (TFE3))

Autre désignation: TFE3

Sujet: The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1), it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.

UniProt: P19532