TLK2 anticorps (AA 141-171)

N° du produit ABIN3029189

Détail du produit anti-TLK2 anticorps

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Épitope: AA 141-171

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLK2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Purified

Immunogène: A portion of amino acids 141-171 from the human protein was used as the immunogen for this TLK2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the TLK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TLK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur TLK2

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Autre désignation: TLK2 (TLK2 Produits)

Synonymes: anticorps tlk2, anticorps MGC149057, anticorps HsHPK, anticorps PKU-ALPHA, anticorps wu:fi16h09, anticorps wu:fi30g12, anticorps zgc:136697, anticorps 4933403M19Rik, anticorps PKUalpha, anticorps Tlk, anticorps tousled like kinase 2, anticorps tousled-like kinase 2, anticorps tousled-like kinase 2 (Arabidopsis), anticorps tlk2, anticorps TLK2, anticorps Tlk2

Sujet: TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

UniProt: Q86UE8