ATG12 anticorps (N-Term)

N° du produit ABIN497963

L’anticorps Lapin Polyclonal anti-ATG12 a été validé pour WB, IHC (p) et EIA. Il convient pour détecter ATG12 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ATG12 anticorps (N-Term) (ABIN497963)

Antigène: ATG12 (Autophagy Related 12 (ATG12))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG12 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-ATG12 anticorps

Épitope: N-Term

Specificité: Recognizes APG12/ATG12.

Purification: Affinity Chromatography purified via peptide column.

Immunogène: A 16 amino acid peptide from near the amino terminus of Human ATG12.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: ATG12 antibody can be used for the detection of ATG12 at 0.5-1 μg/mL. Immunohistochemistry on Paraffin Sections. Positive Control. Human Brain Tissue Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ATG12

Antigène: ATG12 (Autophagy Related 12 (ATG12))

Autre désignation: ATG12 / APG12

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5, this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.Synonyms: APG12-like, APG12L, Autophagy-related protein 12, Ubiquitin-like protein ATG12

ID gène: 9140

NCBI Accession: NP_004698

UniProt: O94817

Pathways: Autophagy