TAO Kinase 1 (TAOK1) (C-Term) anticorps

N° du produit ABIN498003

Cet anticorps anti-TAO Kinase 1 Polyclonal Lapin (ABIN498003) détecte spécifiquement TAO Kinase 1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour TAO Kinase 1 (TAOK1) (C-Term) anticorps (ABIN498003)

Antigène: TAO Kinase 1 (TAOK1)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit

Épitope: C-Term

Specificité: Reacts with TAO Kinase 1 (TAOK1).

Réactivité croisée (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: TAOK1 antibody was raised against synthetic peptide from human TAOK1. .Remarks: Rat Identity: 100% Rat Similarity: 100%

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on Formalin Fixed Paraffin Embedded Tissues: 5 μg/mL (Requirespretreatment with Proteinase K).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Détail du antigène

Antigène: TAO Kinase 1 (TAOK1)

Sujet: TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, TAOK1 activity enhanced microtubule dynamics through activation of Mark and led to phosphorylation and detachment of microtubule-associated proteins from microtubules. TAOK1 also activated JNK in vitro. Overexpression of TAOK1 in a human nonsmall cell lung carcinoma cell line induced apoptotic morphologic changes, including cell contraction, membrane blebbing, and apoptotic body formation. Apoptotic stimuli increased the catalytic activity of endogenous TAOK1 and JNK, and dominant-negative JNK or JNK inhibition blocked the apoptotic morphologic responses to TAOK1. TAOK1 also stimulated cleavage and activation of ROCK1 by caspases, leading to cell contraction and membrane blebbing. TAOK1 was itself a substrate for caspase-3. TAOK1 is indeed involved in the execution phase of apoptosis.Synonyms: KFC-B, KIAA1361, Kinase from chicken homolog B, MAP3K16, STE20-like kinase PSK2, Serine/threonine-protein kinase TAO1, Thousand and one amino acid protein 1

ID gène: 57551

NCBI Accession: NP_065842

UniProt: Q7L7X3