TDGF1 anticorps (Internal Region)

N° du produit ABIN498045

Détail du produit anti-TDGF1 anticorps

Antigène: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp TDGF1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Séquence: YGRNCEHDVR KEN

Specificité: Recognizes CRIPTO

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_003203.1. Genename: TDGF1

Information d'application

Indications d'application: Peptide ELISA: Detection Limit: 1/128000. Western blot: Preliminary experiments in Human Umbilical Cord lysates and in lysates ofcell lines HEK293 and NIH3T3 gave no specific signal but low background (at antibodyconcentration up to 2 μg/mL). Immunohistochemistry: 3-5 μg/mLIn paraffin embedded Human Placenta shows stainng assocated with nuclei in sometrophoblasts and weak cytoplasm staining in cytotrophoblasts.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20 °C.

Détails sur TDGF1

Antigène: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Autre désignation: TDGF1 / CRIPTO (TDGF1 Produits)

Synonymes: anticorps CR, anticorps CRGF, anticorps CRIPTO, anticorps CR1, anticorps cripto, anticorps cb85, anticorps tdgf1, anticorps wu:fe01d04, anticorps zgc:109829, anticorps Cripto-1, anticorps cr1, anticorps cr1a, anticorps frl-1, anticorps frl1, anticorps xcr1, anticorps TDGF1, anticorps tdgf3, anticorps cripto-3, anticorps teratocarcinoma-derived growth factor 1, anticorps teratocarcinoma-derived growth factor 1, member 3 L homeolog, anticorps teratocarcinoma-derived growth factor 1, member 1, anticorps TDGF1, anticorps Tdgf1, anticorps tdgf1, anticorps tdgf1.3.L, anticorps tdgf1.1

Sujet: Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor beta (TGFbeta) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.Synonyms: CRGF, Cripto-1 growth factor, Epidermal growth factor-like cripto protein CR1, Teratocarcinoma-derived growth factor 1

ID gène: 6997

NCBI Accession: NP_003203

UniProt: P13385

Pathways: EGFR Signaling Pathway