HES6 anticorps

N° du produit ABIN498352

Cet anticorps Lapin Polyclonal détecte spécifiquement HES6 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour HES6 anticorps (ABIN498352)

Antigène: HES6 (Hairy and Enhancer of Split 6 (HES6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HES6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HES6 anticorps

Specificité: This antibody detects endogenous levels of HES-6 protein. (region surrounding Ala6)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HES6

Antigène: HES6 (Hairy and Enhancer of Split 6 (HES6))

Autre désignation: HES6

Sujet: The Drosophila hairy and enhancer of split genes encode basic helix-loophelix (bHLH) transcriptional repressors that function in the notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of groucho, and this interaction is mediated by the carboxy-terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N-box (CACNAG) as opposed to the E-box (CANNTG). HES2 binds to both N- and E-box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues.Synonyms: BHLHB41, C-HAIRY1, Class B basic helix-loop-helix protein 41, Hairy and enhancer of split 6, Transcription cofactor HES-6

Poids moléculaire: approx. 30 kDa

ID gène: 55502

NCBI Accession: NP_061115

UniProt: Q96HZ4