ARR3 anticorps

N° du produit ABIN498372

Cet anticorps anti-ARR3 Polyclonal Lapin (ABIN498372) détecte spécifiquement ARR3 dans WB, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ARR3 anticorps (ABIN498372)

Antigène: ARR3 (Arrestin 3, Retinal (X-Arrestin) (ARR3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARR3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ARR3 anticorps

Specificité: This antibody detects endogenous levels of Arrestin-C protein. (region surrounding Glu374)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ARR3

Antigène: ARR3 (Arrestin 3, Retinal (X-Arrestin) (ARR3))

Autre désignation: Arrestin C / ARR3

Sujet: Members of Arrestin/beta-Arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters or sensory signals. Arrestin-C, also known as retinal cone Arrestin-3, X-Arrestin or cArr, is a member of the Arrestin family of proteins. It is predominantly found in the retina and pineal gland and localizes to the inner and outer segments of red-, green- and blue-cone photoreceptors and the inner plexiform regions. Two Arrestin-C isoforms exist due to alternative splicing. Isoform 1 is the mature full length protein and isoform 2 is truncated, ending with an arginine for amino acid residue 359. Arrestin-C expression is stimulated by retinoic acid. It may play a role in retina-specific signal transduction and bind to photoactivated-phosphorylated red/green opsins. In addition, Arrestin-C forms homodimers and oligomers with beta-Arrestins and may regulate beta-Arrestin mediated signaling.Synonyms: ARRX, C-ARR, C-Arrestin, CAR, Cone arrestin, Retinal cone arrestin-3, X-arrestin

Poids moléculaire: approx. 40 kDa

ID gène: 407

NCBI Accession: NP_004303

UniProt: P36575

Pathways: Phototransduction, Thromboxane A2 Receptor Signaling