PAX1 anticorps

N° du produit ABIN498514

Détail du produit anti-PAX1 anticorps

Antigène: PAX1 (Paired Box 1 (PAX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Pax-1 protein. (region surrounding Thr367)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % (by SDS-PAGE)

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur PAX1

Antigène: PAX1 (Paired Box 1 (PAX1))

Autre désignation: PAX1 (PAX1 Produits)

Synonymes: anticorps hup48, anticorps pax-1, anticorps HUP48, anticorps Pax-1, anticorps hbs, anticorps hunchback, anticorps un, anticorps undulated, anticorps wt, anticorps paired box 1, anticorps paired box 1 S homeolog, anticorps PAX1, anticorps pax1, anticorps Pax1, anticorps pax1.S

Sujet: Pax genes contain paired domains with strong homology to genes in Drosophila that are involved in programming early development. Pax-1 is a sequence-specific DNA binding-protein with transcriptional activating properties. The expression pattern of Pax-1 during mouse embryogenesis indicates that it may play an important role in the development of the vertebral column. The autosomal recessive mutation 'undulated' (un) in the mouse exhibits vertebral anomalies along the entire rostrocaudal axis and is associated with a point mutation (G-to-A transition) at position 15 leading to a gly-to-ser replacement in a highly conserved region of the paired box of Pax-1. Pax-1 is required for the normal development of these three skeletal elements: the vertebral column, sternum, and scapula. Mice who are doubly heterozygous for the mutants 'undulated' and 'Patch' have a phenotype reminiscent of an extreme form of spina bifida occulta in humans. The gene which encodes Pax-1 maps to human chromosome 20p11.2.Synonyms: HUP48, Paired box protein Pax-1, Pax-1

Poids moléculaire: approx. 36 kDa

ID gène: 5075

NCBI Accession: NP_006183

UniProt: P15863