Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Antigène
SLC22A6
(Solute Carrier Family 22 Member 6 (SLC22A6))
anticorps HOAT1, anticorps OAT1, anticorps PAHT, anticorps ROAT1, anticorps NKT, anticorps Oat1, anticorps Orctl1, anticorps mOat1, anticorps slc22a6, anticorps zgc:77073, anticorps SLC22A6, anticorps Paht, anticorps Roat1, anticorps nkt, anticorps oat1, anticorps oat1-B, anticorps paht, anticorps roat1, anticorps slc22a6-B, anticorps Slc22a6, anticorps solute carrier family 22 member 6, anticorps solute carrier family 22 (organic anion transporter), member 6, anticorps solute carrier family 22 (organic anion transporter), member 6, like, anticorps Solute carrier family 22 member 6, anticorps solute carrier family 22 (organic anion transporter), member 6 S homeolog, anticorps SLC22A6, anticorps Slc22a6, anticorps slc22a6l, anticorps s22a6, anticorps slc22a6.S
Sujet
SOAT1 (sterol O-acyltransferase 1), also designated ACAT1, is a homotetrameric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl coenzyme A. The gene encoding human SOAT1 maps to chromosome 1 and is expressed as a protein that localizes to the endoplasmic reticulum (ER) in several tissues, including liver, kidney, adrenal glands and macrophages. SOAT1 is involved in cellular cholesterol homeostasis as well as in foam cell formation and the subsequent progression of atherosclerosis. Several SOAT inhibitors have been developed for the treatment of atherosclerosis. SOAT2 (sterol Oacyltransferase 2), also known as ACAT2 (acyl coenzyme A), participates in lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. SOAT2 is an integral membrane protein that localizes to the ER of human intestinal cells. SOAT2 deficiency contributes to severe mental retardation and hypotonus.Synonyms: Organic anion transporter 1, PAH transporter, PAHT, ROAT, Renal organic anion transporter 1, Solute carrier family 22 member 6