Superoxide dismutase copper chaperone anticorps

N° du produit ABIN499056

Cet anticorps anti-Superoxide dismutase copper chaperone Polyclonal Lapin (ABIN499056) détecte spécifiquement Superoxide dismutase copper chaperone dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Superoxide dismutase copper chaperone anticorps (ABIN499056)

Antigène: Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Superoxide dismutase copper chaperone est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Superoxide dismutase copper chaperone anticorps

Specificité: This antibody detects endogenous levels of CCCS protein. (region surrounding Pro271)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Superoxide dismutase copper chaperone

Antigène: Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))

Autre désignation: CCS

Sujet: Cu-Zn superoxide dismutase-1 (SOD-1) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Copper chaperone for SOD-1 (CCS) is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. CCS interacts with both wildtype and mutated forms of SOD-1 through CCS domains that are homologous in SOD-1. CCS exists as a homodimer that may form a heterodimer with SOD-1 during copper loading. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. The gene for CCS maps to human chromosome 11q13.Synonyms: SOD-4, Superoxide Dismutase Copper Chaperone

Poids moléculaire: approx. 32 kDa

ID gène: 9973

NCBI Accession: NP_005116

UniProt: O14618

Pathways: Transition Metal Ion Homeostasis