FOLR1 anticorps

N° du produit ABIN499072

Cet anticorps Lapin Polyclonal détecte spécifiquement FOLR1 dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour FOLR1 anticorps (ABIN499072)

Antigène: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOLR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FOLR1 anticorps

Specificité: This antibody detects endogenous levels of FR-α (Y80) protein. (region surrounding Tyr80)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % (by SDS-PAGE)

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur FOLR1

Antigène: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Autre désignation: Folate Receptor alpha

Sujet: Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, α, β, γ, γ' (which is produced by alternative splicing) and δ. β-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. γ-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of δ-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The α isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.Synonyms: Adult folate-binding protein, FOLR, FOLR1, FR-alpha, Folate receptor 1, KB cells FBP, MOv18, Ovarian tumor-associated antigen MOv18

Poids moléculaire: approx. 34 kDa

ID gène: 2348

NCBI Accession: NP_000793

UniProt: P15328

Pathways: Dicarboxylic Acid Transport