AFAP1L2 anticorps (C-Term)

N° du produit ABIN499229

L’anticorps Lapin Polyclonal anti-AFAP1L2 a été validé pour WB, IHC (p) et EIA. Il convient pour détecter AFAP1L2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour AFAP1L2 anticorps (C-Term) (ABIN499229)

Antigène: AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AFAP1L2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-AFAP1L2 anticorps

Épitope: C-Term

Specificité: This anitbody reacts to AFAP1L2.

Purification: Affinity chromatography purified via peptide column

Immunogène: AFAP1L2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human AFAP1L2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: AFAP1L2 antibody can be used for detection of AFAP1L2 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur AFAP1L2

Antigène: AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))

Autre désignation: AFAP1L2

Sujet: AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3b, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.Synonyms: AFAP1-like protein 2, Actin filament-associated protein 1-like 2, KIAA1914, XB130

ID gène: 84632

NCBI Accession: NP_001001936

UniProt: Q8N4X5

Pathways: EGFR Signaling Pathway