AICDA anticorps (C-Term)

N° du produit ABIN499233

Cité dans 1 publication. Cet anticorps anti-AICDA Polyclonal Lapin (ABIN499233) détecte spécifiquement AICDA dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour AICDA anticorps (C-Term) (ABIN499233)

Antigène: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AICDA est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-AICDA anticorps

Épitope: C-Term

Specificité: This antibody recognizes AID (C-term).

Purification: Affinity chromatography purified via peptide column

Immunogène: A Peptide corresponding to 14 amino acids near the carboxy-terminus of Human AID

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: AID antibody can be used for detection of AID at 1 - 2 μg/mL. Whole cell lysatefrom Ramos cells can be used as positive control. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-AICDA (ABIN499233)

Milillo, Molinario, Costanzi, Vischini, La Carpia, La Greca, Rigante, Gambaro, Gurrieri, Sangiorgi: "Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura." dans: Journal of nephrology, Vol. 31, Issue 5, pp. 731-741, (2018) (PubMed).

Détails sur AICDA

Antigène: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Autre désignation: AICDA / AID

Sujet: Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5).Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase

ID gène: 57379

NCBI Accession: NP_065712

UniProt: Q9GZX7

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response