AKIRIN2 anticorps (Center)

N° du produit ABIN499259

Détail du produit anti-AKIRIN2 anticorps

Antigène: AKIRIN2 (Akirin 2 (AKIRIN2))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKIRIN2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to AKIRIN-2.

Purification: Affinity chromatography purified via peptide column

Immunogène: Akirin2 antibody was raised against a 15 amino acid peptide near the center of the human Akirin2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Akirin2 antibody can be used for detection of Akirin2 at 0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur AKIRIN2

Antigène: AKIRIN2 (Akirin 2 (AKIRIN2))

Autre désignation: AKIRIN2 / C6orf166 (AKIRIN2 Produits)

Synonymes: anticorps MGC76154, anticorps c6orf166, anticorps C6orf166, anticorps wu:fb16h11, anticorps wu:fi04e05, anticorps zgc:114001, anticorps zgc:55291, anticorps zgc:77169, anticorps FBI1, anticorps dJ486L4.2, anticorps 2700059D21Rik, anticorps AA114675, anticorps AA522011, anticorps AU019887, anticorps Akirin-2, anticorps RGD1307791, anticorps C9H6ORF166, anticorps akirin-2, anticorps akirin 2, anticorps akirin 2 S homeolog, anticorps akirin2, anticorps akirin2.S, anticorps AKIRIN2, anticorps Akirin2

Sujet: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.Synonyms: Akirin-2

ID gène: 55122

UniProt: Q53H80

Pathways: Positive Regulation of Endopeptidase Activity